Not for resale without express authorization. View Rabbit Polyclonal anti-DFF45/ICAD Antibody (NBP1-77034). Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.įor Research Use Only. There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells.
In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. The apoptotic process is accompanied by shrinkage and. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. DFFA is a cell death process that removes toxic and/or useless cells during mammalian development. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45 and a 35kDa isoform, ICAD-S/DFF35.
Expression of mFas and sensitivity to anti - Fas antibody in primary ATLL. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. inhibitory protein CAD : caspase - activated DNase ICAD : inhibitor of CAD. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis.